|
KMID : 0350519930460030997
|
|
Journal of Catholic Medical College
1993 Volume.46 No. 3 p.997 ~ p.1004
|
|
|
Perinatal Stress and Lipid Levels of Cord Sera
|
|
|
|
|
Abstract
|
|
|
There is increasing conviction that the way to reduce the risk factor for atherosclerosis is early interventon, because the atherosclerotic change foten begins in early childhood. There is still a scarcity of information, unfortunately, on the
normal
distribution of serum lipid and lipoproteins, and factors that influence the lipid concentrations.
In this study, total cholesteral(TC), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) and triglyceride(TG) levels in cord sera were determined in 60 full term normal infants and 40 preterm or/with other
perinatal
complications, and in their maternal sera concomitantly for comparison.
@ES The results obtained were as follows :
@EN 1. In preterm newborn infants(gestational age<37 weeks), the TC level was slightly higher than in term newborn infants : mean were 106.5 and 98.51 mg/100ml respectively. The HDL-C level was slightly lower than in term : mean values were 36.93
and
48.35 mg/100 ml respectively.
The LDL-C level was significantly higher than in term(P<0.05 : mean values were 59.54 and 37.25 mg/100 ml. The mean levels of TG were 51.64 and 54.90 mg/100 ml respectively.
In mothers, the mean levels of lipld excelt LDL-C were no significant differerce between preterm and fuli term. The mean levels of TC were : 263.38 and 253.70 mg/100 ml, the HDL-C lcvels : 64.8 and 78.87 mg/100 ml, and the TG levels : 234.19 and
239.45
mg/100 ml respectively. The LDL-C level in preterm mother was significantly higher than in term mother : mean levels were 148.52 and 119.93 g/100 ml(P<0.05).
2. In low birth weight newborn infants( <2.5 kg), the TC level was slightly higher than in 3.0 to 3.5 kg(Korean standard birth weight group, SBW) newborn : mean values were 118.42 and 99.64 mg/100 ml. The HDL-C level was slighily lower than in
SBW
;
mean values were 46.16 and 50.22mg/100 ml and the LDL-C level was significantly higher than in SBW(p<0.05) : mean values were 68.24 and 36.29 mg/100 ml. The mean levels of TG were 56.64 and 56.92/100 ml repectively.
3. In perinatal high risk newborn infants, the TC level was slightly higher than in uncomplicated newborn infants : mean values were 105.43 and 96.29 mg/100 ml. The HDL-C level was slightly lower than in unocomplicated : mean values were 41.56
and
51.27 mg/100 ml. The LDL-C level was significantly higher than in uncomplicated(P<0.05) : mean values were 52.19 and 34.54 mg/100 ml. The mean levels of TG were 57.45 and 54.22 mg/100 ml respecively.
Of high risk newborns, the LDL-C leelwas much higher in newborns with low Apgan score and low birth weight.
In mothers, all lipid levels between in high risk and uncomplicated group show little differeance.
In summary, it may be obligatory to screen the lipid and lipoprotein levels in cord sera of the newborn infant with perinatal complications to identify hyperlipidemia, and the elevated LDL-C level needs follw up whether it may be transient or
true
hyperlipidemia.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|